The Cherokee Garden Club of Atlanta, Georgia, was formed on March 10, 1928 and is Atlanta's second oldest garden club. The club was organized for "the study and culture of flowers, landscape gardening, protection of natural trees, plants, and birds, and the encouragement of civic planting." In 1928, the club was one of the eleven founding clubs of The Garden Club of Georgia and also a founding club of the Atlanta Garden Center and the Atlanta Flower Show Association. In 1963, the club was invited to join the Garden Club of America and also joined the National Council of Garden Clubs, Inc., the Georgia Conservancy, Inc., and the National Trust for Historic Preservation. Governed by elected officers such as president, vice-president, and treasurer, the club's first civic project was the 1928 planting of the Dolly Blalock Black Memorial Garden at Egleston Hospital on Forrest Avenue, Atlanta designed by Norman C. Butts. The club hired Edward L. Daugherty in 1969 to design a garden for the blind called the Fragrance Garden in Piedmont Park with club member Eleanor Morgan Montgomery. The garden was refurbished in 1973 and expanded into the "Fragrance and Texture Garden," which was later incorporated into the Atlanta Botanical Garden.

In 1975, under the leadership of past club president Anne Coppedge Carr, the club established the Cherokee Garden Library, housed at the Atlanta Historical Society (later the Atlanta History Center) to serve as an educational repository for garden and horticultural records for the Southeast. In 2001, the Garden Club of America awarded Anne Carr the prestigious Amy Angell Collier Montague Medal for the creation and development of the Cherokee Garden Library. Cherokee Garden Club has participated in numerous flowers shows beginning in 1929, with Peachtree Garden Club's annual flower show and continues to participate and host flower shows and exhibitions, winning numerous awards. The club is an active member of the Garden Club of America, with members serving on many committees in Zone VIII and on the national level. The club has also hosted many zone and annual meetings for the Garden Club of America.